Comprehensive Vasculitis Panel

What is Comprehensive Vasculitis Panel test?

The Comprehensive Vasculitis Panel is a group of blood tests designed to detect autoantibodies and markers of inflammation associated with vasculitis, a condition where blood vessels become inflamed. This inflammation can restrict blood flow and damage vital organs and tissues.
The panel typically includes tests such as ANCA (Anti-Neutrophil Cytoplasmic Antibodies), ANA (Antinuclear Antibody), Anti-dsDNA, Complement levels (C3, C4), and other related autoantibodies. These help identify the type and severity of vasculitis and differentiate it from other autoimmune or inflammatory disorders.

Parameters Covered:  CRP (QUANTITATIVE), ANGIOTENSIN CONVERTING ENZYME (ACE), RHEUMATOID FACTOR ANTIBODIES, ANCA POSITIVE REFLEX MPO, PR3 ANTIBODIES, ANTI-NUCLEAR AB-IFA, HEP2, DSDNA (REFLEX TO END TITRE FOR ALL POSITIVE CASES), ANTI GLOMER- ULAR BASEMENT MEMBRANE IGG ANTIBODIES (ANTI GBM)

Why consider Comprehensive Vasculitis Panel test?

Comprehensive Vasculitis Panel test can be considered if a doctor suspects systemic or localized vasculitis or other autoimmune vascular disorders. It helps to:

• Detect autoimmune antibodies linked to various vasculitic diseases.
• Aid in early diagnosis and management of conditions such as Wegener’s granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, or lupus vasculitis.
• Monitor disease activity and treatment response in patients already diagnosed with vasculitis.
• Differentiate vasculitis from infections or other causes of inflammation.

Who should get tested for Comprehensive Vasculitis Panel test?

Comprehensive Vasculitis Panel test is recommended for individuals who have:

• Unexplained inflammation or elevated ESR/CRP levels.
• Symptoms such as persistent fever, joint pain, muscle pain, fatigue, rashes, or nerve problems.
• Organ-specific issues, such as kidney dysfunction, lung involvement, or skin ulcers with suspected autoimmune causes.
• A known autoimmune disease, to check for possible vasculitic complications.

More Information

OTHER NAMES: Vasculitis Autoimmune Panel, Autoimmune Vasculitis Screening Panel, Systemic Vasculitis Evaluation

Vasculitis is a group of disorders that cause inflammation of blood vessels — arteries, veins, or capillaries. This inflammation can thicken, weaken, narrow, or scar the vessel walls, restricting blood flow and leading to tissue or organ damage. Depending on which blood vessels and organs are affected, vasculitis can range from mild and short-term to severe and life-threatening.