Mpn Reflex Panel

What is MPN Reflex Panel Test?

 

The MPN Reflex Panel is a genetic blood test that diagnoses and classifies myeloproliferative neoplasms (MPNs), a type of blood cancer where the bone marrow produces too many blood cells. The test analyses key genes BCR ABL QUALITATIVE, JAK2 V617F MUTATION DETECTION, CALR GENE MUTATION DETECTION, JAK2 EXON 12 MUTATION DETECTION, MPL MUTATION DETECTION

 

Why consider MPN REFLEX PANEL Test?

• Diagnostic clarity: Identifies canonical driver mutations present in the vast majority of non‑CML MPNs (JAK2 in most PV and ~50–60% ET/PMF; CALR in many JAK2‑negative ET/PMF; MPL in a smaller subset), distinguishing clonal disease from reactive cytoses.
• Prognosis and management: Mutation class and burden support risk stratification (e.g., thrombotic risk in PV/ET), influence cytoreductive therapy decisions, and inform transplant considerations in MF.
• Efficiency: Reflexing automatically when the preceding test is negative minimizes repeat phlebotomy, shortens time to result, and ensures adherence to evidence‑based testing order.

Who should get this MPN REFLEX PANEL Test?

• Individuals with persistent erythrocytosis, thrombocytosis, or leukocytosis where clinical evaluation suggests a clonal MPN rather than reactive causes.
• Patients with suspected PV (JAK2 V617F/exon 12), ET, or PMF after initial clinical, CBC, and marrow findings; also considered in MDS/MPN overlap with thrombocytosis to clarify driver status

 

More Information

OTHER NAMES:

Myeloproliferative Neoplasm Reflex Panel BCR ABL QUALITATIVE, JAK2 V617F MUTATION DETECTION, CALR GENE MUTATION DETECTION, JAK2 EXON 12 MUTATION DETECTION, MPL MUTATION DETECTION Non‑CML MPN Molecular Panel, MPN Core Diagnostic Panel

 

The panel's comprehensive genetic analysis helps to accurately diagnose and classify various myeloproliferative neoplasms.

By identifying specific genetic mutations, the test provides valuable information for physicians to make appropriate treatment plans and manage the condition effectively.