Tryptase, Serum

Tryptase, Serum

About this test

Test measures the level of tryptase, an enzyme released by mast cells, in the blood. It is commonly used to help diagnose mast cell-related disorders, such as systemic mastocytosis or to evaluate allergic reactions, including anaphylaxis. Elevated tryptase levels can indicate excessive mast cell activation or increased mast cell numbers.

Why consider this test?

This test is consider to diagnose or monitor conditions involving abnormal mast cell activity, such as allergic reactions or mastocytosis. It helps confirm if symptoms like severe allergic responses or unexplained anaphylaxis are related to mast cell release. Measuring tryptase levels can also guide treatment decisions and assess the severity of allergic events. Early detection aids in managing these conditions effectively.

Who should get this test done?

• Individuals with severe or unexplained allergic reactions
• People who have experienced anaphylaxis (life-threatening allergic shock)
• Patients with recurrent hives, flushing, or swelling without clear cause
• Those suspected of having mast cell disorders like systemic mastocytosis
• After insect stings or exposure to allergens causing severe symptoms

More Information

Tryptase is an enzyme released primarily by mast cells during allergic reactions. Measuring its levels helps identify mast cell activation and can confirm allergic responses or mast cell diseases. The test is most accurate when done shortly after symptoms begin. It plays a key role in diagnosing and managing allergic and mast cell-related conditions.

Other Names: Serum Tryptase, Mast Cell Tryptase