Hla –dp Locus Typing

What is HLA-DP Locus Typing test?

A HLA-DP locus typing test identifies a person's specific Human Leukocyte Antigen (HLA) genes, particularly the DP locus genes, which are part of the Major Histocompatibility Complex (MHC). This genetic information helps determine immune compatibility in organ and tissue transplants (like bone marrow), as matching HLA-DP genes between a patient and donor reduces the risk of organ rejection. The test analyzes DNA from a blood sample using molecular techniques to identify the precise HLA-DP alleles.

Why consider HLA-DP Locus Typing test?

• Transplant compatibility: HLA‑DP mismatches and donor‑specific anti‑DP antibodies can contribute to antibody‑mediated rejection and adverse outcomes; precise DP typing complements DR and DQ for a fuller class II risk picture.
• Extended matching: Many centers now consider DPB1 matching or permissive DPB1 mismatch strategies in HSCT to reduce graft‑versus‑host disease and improve outcomes, making accurate DP typing clinically actionable.
• Antibody mapping: Knowing exact DP alleles improves interpretation of class II donor‑specific antibodies on solid‑phase assays and helps anticipate crossmatch results.

Who should get tested for HLA-DP Locus Typing test?

• Transplant candidates and donors: Individuals evaluated for HSCT and solid‑organ transplantation when multi‑locus class II typing (DR, DQ, DP) informs donor selection and risk stratification.
• Sensitized recipients: Patients with class II antibodies where DP allele data refines virtual crossmatch and guides desensitization and monitoring plans before donor offers.
• Donor registries/cord units: Programs incorporating DPB1 typing to optimize unrelated donor searches and apply permissive DP mismatch frameworks in HSCT.

More Information about HLA-DP Locus Typing test

HLA is central to transplant compatibility: matching donor and recipient HLA types and ensuring no donor‑specific HLA antibodies are present reduces rejection risk, improves graft survival, and guides immunosuppression strategies. A mismatch between a donor's and recipient's HLAs can trigger an immune response, leading to graft (transplanted organ or tissue) rejection. HLA matching aims to find a donor whose HLAs are as similar as possible to the recipient's, which increases the likelihood of graft acceptance and reduces the risk of rejection and other complications.

OTHER NAMES: HLA‑DP typing / HLA‑DPA1 and ‑DPB1 allele typing, High‑resolution HLA‑DP genotyping, HLA class II (DP locus) DNA typing.