Kinship Hexa

What is Kinship analysis (Hexa) test?

Kinship analysis (Hexa) test is a DNA relationship analysis used in transplant workflows to verify a claimed biological relationship between a living donor and recipient by testing six individuals together (typically donor, recipient, and five additional relative such as a parent)

Why consider Kinship analysis (Hexa) test?

A kinship analysis (Hexa) test is a type of genetic testing used to determine biological relationships between individuals. It is also important as it is superior to HLA for relationship proof and it strengthens transplant workup

Who should get tested for Kinship analysis (Hexa) test?

• Living related donor evaluations: Donor–recipient pairs claiming parent–child or sibling relationships where the committee requires genetic confirmation, ideally using a trio that includes an additional informative relative to increase certainty.
• Ambiguous or complex pedigrees: Cases with limited records, adoption, or uncertain parentage where standard documents and HLA patterns are inconclusive, and a third relative can clarify the relationship.
• Transplant centers standardizing documentation: Programs that include kinship verification in their eligibility workflow alongside HLA typing, crossmatch, and antibody profiling to meet institutional and committee expectations.

More Information about Kinship analysis (Hexa) test

Kinship testing for transplant uses autosomal STR profiling, with lineage markers like Y‑STR and mtDNA when needed, to prove donor–recipient relatedness independent of HLA similarity, which alone cannot reliably establish relationships due to polymorphism and ambiguity in HLA genes.

Other Names:  Kinship DNA test, DNA profiling, Kinship analysis, DNA fingerprinting test, Relationship analysis test