Hla B27 By Pcr

The HLA-B27 test by PCR is used to detect the presence of the HLA-B27 gene. This gene is a marker for a group of autoimmune disorders, particularly ankylosing spondylitis, a form of spinal arthritis. PCR (Polymerase Chain Reaction) amplifies the DNA to detect the HLA-B27 gene variant.

• Diagnosing autoimmune diseases: This test is commonly used to help diagnose ankylosing spondylitis, reactive arthritis, and other conditions like psoriatic arthritis or inflammatory bowel disease.
• Risk assessment: HLA-B27 is strongly associated with certain autoimmune conditions, and its presence can suggest a predisposition to these disorders.

• Individuals with symptoms of spinal arthritis or joint pain, especially if there's a family history of these conditions.
• People with symptoms of inflammatory bowel disease or psoriasis.

Not all people with the HLA-B27 gene develop autoimmune diseases, but its presence increases the likelihood. The test is primarily used in conjunction with other clinical signs and symptoms.