HLA –A B C DRB1 DQB1 DPB1 Loci Typing High Resolution

What is HLA –A, B, C, DRB1, DQB1, DPB1 high resolution Loci Typing test?

High-resolution HLA typing determines a person’s exact HLA alleles at six key loci—Class I (HLA‑A, ‑B, ‑C) and Class II (HLA‑DRB1, ‑DQB1, ‑DPB1)—typically using next‑generation sequencing. High resolution HLA typing improves the accuracy of donor–recipient matching, the identification of donor‑specific antibodies (DSA), and immunologic risk assessment compared with limited or low‑resolution typing.

Why consider HLA –A, B, C, DRB1, DQB1, DPB1 high resolution Loci Typing test?

• Improves transplant matching and outcomes: High‑resolution matching at HLA‑A, ‑B, ‑C, and ‑DRB1 is associated with better survival and fewer rejection events in hematopoietic and solid‑organ transplantation.
• Better antibody assessment: Complete six‑locus high‑resolution typing refines interpretation of preformed and de novo DSA, particularly for DQ and DP, and discriminates which antibodies are truly donor‑specific and clinically relevant.
• Enables precise virtual crossmatch

Who should get this HLA –A, B, C, DRB1, DQB1, DPB1 high resolution Loci Typing test?

• Hematopoietic stem cell transplant candidates and their potential related/unrelated donors to achieve optimal allele‑level matching (aiming for 8/8 at A, B, C, DRB1, with expansion to DQB1/DPB1 per protocol).
• Solid‑organ transplant candidates and recipients, especially those sensitized or with prior transplants/transfusions/pregnancies, to define unacceptable antigens, perform accurate virtual crossmatch, and monitor risk of antibody‑mediated rejection.
• Individuals undergoing donor searches via registries or programs that require comprehensive high‑resolution HLA data for match algorithms and allocation.

More Information HLA –A, B, C, DRB1, DQB1, DPB1 high resolution Loci Typing test?

Other Names – HLA Typing, Human Leukocyte Antigen, HLA Typing High resolution, HLA Typing 6 Loci, HLA Typing by NGS, Solid Organ Transplantation, Kidney Transplant, Stem cell transplant, Bone marrow transplant

Human leukocyte antigens are of three main types. Class I HLA antigens include HLA-A, B, and C molecules; class II, which includes HLA-DR, -DQ, and -DP loci, are on antigen-presenting cells; and class III contains genes for proteins that have immune functionality.

HLA class I typing is used to identify HLA-matched platelets for alloimmunized refractory patients and identify presence of HLA antigens associated with a number of diseases or as drug hypersensitivity markers class I HLA antigens include A, B, and C loci.