DSA (Donor Specific IgG Antibodies to Class I & II)
The DSA test detects antibodies in the recipient’s blood that are directed against the donor’s organ after transplantation. It is critical for evaluating transplant rejection and managing post-transplant care. The test helps identify patients at risk for graft rejection.
Overview of DSA (Donor Specific IgG Antibodies to Class I & II) in Jodhpur
What is DSA, Donor Specific IgG Antibodies to Class I & II test?
What is DSA, Donor Specific IgG Antibodies to Class I & II test is a blood test that detects IgG antibodies in a transplant recipient directed specifically against the donor’s HLA Class I (A, B, C) and Class II (DR, DQ, DP) antigens, which are a major cause of antibody‑mediated graft injury and rejection.
Why consider DSA, Donor Specific IgG Antibodies to Class I & II test?
- Presence of DSA is strongly associated with antibody‑mediated rejection (AMR), graft dysfunction, and inferior graft survival across solid organ transplants, making it critical for risk assessment and monitoring.
- Complement‑binding or certain IgG subclasses (notably IgG1/IgG3) indicate higher pathogenic potential, helping refine risk stratification and management decisions.
Who should get this DSA, Donor Specific IgG Antibodies to Class I & II test?
- Transplant candidates during pre‑transplant workup to detect preformed DSA and guide organ acceptance, desensitization, or allocation strategies.
- Post‑transplant recipients for routine surveillance or when there is graft dysfunction, to detect de novo DSA and guide timely interventions.
More Information about DSA, Donor Specific IgG Antibodies to Class I & II test
Donor-specific IgG antibodies are anti-HLA antibodies produced by a transplant recipient that specifically recognize the donor’s HLA Class I (A, B, C) and/or Class II (DR, DQ, DP) antigens, and they are a key biomarker for antibody-mediated rejection and graft injury.
Preformed DSA present before transplant can provoke hyperacute or early acute rejection and influence organ acceptance decisions, particularly if they cause a positive T-cell crossmatch.
Other Names: HLA DSA (Donor‑Specific Antibody) Class I & II; Donor‑specific HLA antibody; DSA monitoring; HLA antibody specificity monitoring
Test included
- Dsa Class I - Mean Fluoroscence Intensity (mfi)
- Dsa Class I Result
- Dsa Class Ii - Mean Fluoroscence Intensity (mfi)
- Dsa Class Ii Result
- Dsa Final Result
Doctor information
Test code
4810
CPT and Loinc codes
Department
- Hla Serology
Turn around time
2 Working Days
Performing locations
3 labs across India
Specimen vol. and vacutainer information
| Specimen | Vacutainer | Volume |
|---|---|---|
| Acd Whole Blood | Yellow Vacutainer | 2 ML |
| Serum | Yellow Vacutainer | 2 ML |
Specimen stability information
Acd Whole Blood, Serum
Collection instructions
Age,Gender,Clinical history required
Package price
₹11500
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