Hla –c Locus Typing

What is HLA-C Locus Typing test?

An HLA-C locus typing test determines an individual's specific Human Leukocyte Antigen C (HLA-C) proteins, which are crucial for immune function and are found on white blood cells. This genetic test helps assess risks for autoimmune diseases, like celiac disease, and is essential for finding compatible donors for organ and bone marrow transplants by preventing immune rejection.

Why consider HLA-C Locus Typing test?

• Transplant compatibility: HLA‑C mismatches contribute to alloimmune risk; precise HLA‑C typing refines donor selection, virtual crossmatch interpretation, and immunosuppression planning, especially when class I antibodies are present.
• Antibody interpretation: Exact HLA‑C allele calls help map donor‑specific antibodies on solid‑phase assays and anticipate crossmatch outcomes to reduce antibody‑mediated rejection.
• Comprehensive matching: Including HLA‑C with HLA‑A and ‑B improves match grading in HSCT and solid organs, aligning with modern protocols that emphasize multi‑locus, higher‑resolution typing.

Who should get tested for HLA-C Locus Typing test?

• Transplant candidates and donors: Individuals evaluated for kidney, liver, heart, lung, or HSCT where multi‑locus HLA typing guides allocation and compatibility decisions.
• Sensitized recipients: Patients with class I antibodies who require precise HLA‑C allele data for virtual crossmatch and risk stratification before donor offers.
• Donor registries/cord units: Programs that type HLA‑C with A, B, DR (±C, DQ, DP at high resolution) to optimize unrelated donor searches and confirmatory testing.

More Information about HLA-C Locus Typing test

HLA is central to transplant compatibility: matching donor and recipient HLA types and ensuring no donor‑specific HLA antibodies are present reduces rejection risk, improves graft survival, and guides immunosuppression strategies. A mismatch between a donor's and recipient's HLAs can trigger an immune response, leading to graft (transplanted organ or tissue) rejection. HLA matching aims to find a donor whose HLAs are as similar as possible to the recipient's, which increases the likelihood of graft acceptance and reduces the risk of rejection and other complications.

OTHER NAMES: HLA‑C typing / HLA‑C allele typing, High‑resolution HLA‑C genotyping, HLA class I (C locus) DNA typing.