C4d Immunofluorescence

About C4d Immunofluorescence test

C4d immunofluorescence is a specialized laboratory test used to detect the presence of the complement fragment C4d in tissue samples, often in kidney biopsies. The deposition of C4d indicates activation of the classical complement pathway, which is commonly associated with antibody-mediated rejection in organ transplants. This test helps clinicians diagnose transplant rejection and guide appropriate treatment.

Why consider C4d Immunofluorescence test?

This test is important because it helps detect antibody-mediated rejection in transplanted organs, especially kidneys. By identifying the presence of C4d deposits in tissue, it provides evidence of immune system activation against the transplant. Early detection through this test allows timely treatment to prevent organ damage and improve transplant outcomes.

Who should get C4d Immunofluorescence test done?

• Patients who have undergone organ transplantation, especially kidney transplants.
• Individuals suspected of having antibody-mediated rejection based on clinical signs or other biopsy findings.
• Transplant recipients showing deterioration in organ function without clear cause.
• Patients undergoing a biopsy to evaluate transplant health and guide immunosuppressive therapy.

More Information about C4d Immunofluorescence

In addition to detecting antibody-mediated rejection, C4d immunofluorescence can also help differentiate between different types of transplant rejection and assess the severity of immune injury. It is often used alongside other diagnostic tests, such as histology and donor-specific antibody testing, to provide a comprehensive evaluation of transplant status. The test improves accuracy in diagnosing rejection, which is critical for timely and effective management.

Other Names: C4d Complement Staining, Complement C4d Deposits Test