Dsa (donor Specific Igg Antibodies To Class I&ii)

What is DSA, Donor Specific IgG Antibodies to Class I & II test?

What is DSA, Donor Specific IgG Antibodies to Class I & II test is a blood test that detects IgG antibodies in a transplant recipient directed specifically against the donor’s HLA Class I (A, B, C) and Class II (DR, DQ, DP) antigens, which are a major cause of antibody‑mediated graft injury and rejection.

Why consider DSA, Donor Specific IgG Antibodies to Class I & II test?

• Presence of DSA is strongly associated with antibody‑mediated rejection (AMR), graft dysfunction, and inferior graft survival across solid organ transplants, making it critical for risk assessment and monitoring.
• Complement‑binding or certain IgG subclasses (notably IgG1/IgG3) indicate higher pathogenic potential, helping refine risk stratification and management decisions.

Who should get this DSA, Donor Specific IgG Antibodies to Class I & II test?

• Transplant candidates during pre‑transplant workup to detect preformed DSA and guide organ acceptance, desensitization, or allocation strategies.
• Post‑transplant recipients for routine surveillance or when there is graft dysfunction, to detect de novo DSA and guide timely interventions.

More Information about DSA, Donor Specific IgG Antibodies to Class I & II test

Donor-specific IgG antibodies are anti-HLA antibodies produced by a transplant recipient that specifically recognize the donor’s HLA Class I (A, B, C) and/or Class II (DR, DQ, DP) antigens, and they are a key biomarker for antibody-mediated rejection and graft injury.

Preformed DSA present before transplant can provoke hyperacute or early acute rejection and influence organ acceptance decisions, particularly if they cause a positive T-cell crossmatch.

Other Names: HLA DSA (Donor‑Specific Antibody) Class I & II; Donor‑specific HLA antibody; DSA monitoring; HLA antibody specificity monitoring