ROS1 Gene Rearrangement by FISH
This test detects ROS1 gene rearrangements, which are often found in certain types of lung cancer. It helps guide targeted therapies for patients with non-small cell lung cancer (NSCLC).
Overview of ROS1 Gene Rearrangement by FISH in Mankundu
What is ROS1 gene rearrangement by FISH test?
ROS1 gene rearrangement by FISH detects the split-apart signals in the ROS1 locus, indicating a ROS1 fusion in tumor cells—most commonly in lung adenocarcinoma—so patients can be considered for ROS1‑targeted tyrosine kinase inhibitors.
Why consider ROS1 gene rearrangement by FISH test?
Clinicians should consider ROS1 gene rearrangement test as
- Identifies ROS1 fusions present in approximately 1–2% of NSCLC, enabling use of effective ROS1 TKIs and improving treatment outcomes compared with chemotherapy.
- Provides high analytical confidence; commonly used to confirm positive or equivocal ROS1 immunohistochemistry results due to IHC’s variable specificity.
- It is recommended for lung cancer patients to determine eligibility for targeted therapy.
Who should get this ROS1 gene rearrangement by FISH test?
ROS1 gene rearrangement test is recommended for patients with late-stage non-small-cell lung cancer (NSCLC) adenocarcinoma who have tested negative for EGFR mutations and ALK rearrangements This is because ROS1 rearrangement acts as a target for specific targeted therapies, like crizotinib, which can be effective in treating this type of cancer.
ROS1 gene rearrangement test helps identify patients who could benefit from such treatments, improving their outcomes.
- Patients with diagnosed NSCLC adenocarcinoma
- Patients who are negative for EGFR and ALK alterations
- Patients with specific characteristics
More Information about ROS1 gene rearrangement by FISH test
The fusion activates ROS1 tyrosine kinase signalling, leading to uncontrolled proliferation via pathways and establishing ROS1 as a true oncogenic driver. Prevalence in NSCLC is typically around 1–2%, frequently in younger, never‑smokers with adenocarcinoma histology, defining a distinct molecular subset
Other Names: ROS1 Rearrangement FISH; ROS1 Fusion by FISH, ROS gene Test, ROS1 Gene Assay, Lung canner ROS1 gene
Test included
- Specimen
- Block Identification Number
- Number Of Observers
- Total Number Of Cells Analysed
- Interpretation
Doctor information
Test code
6032F
CPT and Loinc codes
Department
- Cytogenetics
Turn around time
7 Working Days
Test run frequency
Every Day TIME - 10:00
Performing locations
1 labs across India
Specimen vol. and vacutainer information
| Specimen | Vacutainer | Volume |
|---|---|---|
| Paraffin Block | Others |
Specimen stability information
Paraffin Block
Collection instructions
Formalin-Fixed (10% Buffered Formalin For 24-48 Hrs), Paraffin-Embedded (Ffpe) Tissue Specimens. Transport Tissue Block Or 3 Unstained Slides/ Sample (4-Micron Thick Sections) Containing Malignant Tissue On Positively Charged Slides. * Time And Duration Of Fixation Should Be Mentioned On The Trf.* Required Clinical Details, Include Surgical Pathology Report.
Package price
₹9500
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