Myeloperoxidase (MPO)smear

What is the MPO Stain test?

This histochemical stain is used to detect myeloperoxidase enzyme activity in white blood cells, particularly useful in identifying myeloid cells.


Why is this test done?

It is primarily used to help differentiate types of leukemia, especially distinguishing myeloid leukemia from lymphoid leukemia.


How is the test performed?

Bone marrow or blood smears are stained in the lab and observed under a microscope for MPO enzyme activity.


What do the results mean?

Positive staining supports the diagnosis of acute myeloid leukemia. Lack of MPO may point to lymphoid malignancies or specific subtypes of leukemia.


Are there any precautions or preparations required?

No specific preparation is needed, but the procedure used to obtain the sample (e.g., bone marrow aspiration) may require preparation.