Alkaline Phosphatase, Serum

The Alkaline Phosphatase (ALP) test measures the level of alkaline phosphatase, an enzyme found in various organs throughout the body, including the liver, bones, kidneys, and bile ducts. ALP is involved in breaking down proteins and plays an important role in bone health, liver function, and bile production. Elevated or decreased levels of ALP can indicate a variety of health conditions related to these organs.

This test is recommended when there are concerns related to liver function, bone health, or other metabolic conditions. High ALP levels may indicate liver disease (such as cirrhosis or bile duct obstruction) or bone disorders (like Paget's disease or bone cancers). Conversely, low ALP levels could point to conditions such as malnutrition, zinc deficiency, or certain rare metabolic disorders. It’s an important diagnostic tool to help assess and monitor these conditions, and it is commonly done alongside other tests to give a more complete picture of your health.

• Individuals with symptoms of liver disease, such as jaundice, abdominal pain, dark urine, or unexplained weight loss
• Those with bone pain, fractures, or deformities that might indicate bone disorders
• People who have a family history of liver or bone conditions that may affect ALP levels
• Individuals being treated for liver disease, bone conditions, or metabolic disorders
• Those who have abnormal results from routine health screenings and need further evaluation of their liver and bone health

The ALP test is commonly ordered as part of a liver function test or a metabolic panel. Abnormal ALP levels can point to a wide range of health issues, from liver disease (like cirrhosis or hepatitis) to bone disorders (like Paget’s disease or osteomalacia). Because ALP levels can be naturally higher in children and pregnant women, it’s important for the results to be interpreted in the context of your overall health and other lab findings.