Ace (angiotensin Converting Enzyme), Serum

The ACE (Angiotensin-Converting Enzyme) test measures the level of angiotensin-converting enzyme in your blood. ACE is an enzyme that plays a crucial role in the body’s blood pressure regulation and fluid balance. It converts angiotensin I to angiotensin II, a substance that constricts blood vessels and increases blood pressure. The ACE test is primarily used to help diagnose or monitor conditions like sarcoidosis, a disease involving the growth of inflammatory cells in the body, and can also be useful in evaluating other conditions like certain lung diseases, or to assess the effectiveness of treatment for such conditions.

The ACE test is typically ordered when there is suspicion of sarcoidosis, a disease that causes inflammation and the formation of granulomas (small clusters of immune cells) in various organs, especially the lungs and lymph nodes. Elevated ACE levels are often seen in individuals with sarcoidosis, although high levels can also occur in other conditions such as tuberculosis, certain cancers, and some genetic disorders. The test may also be used to monitor treatment effectiveness in individuals with sarcoidosis or to assess the progression of the disease.

Individuals who may benefit from the ACE test include:

• People who are being evaluated for sarcoidosis, especially if they have symptoms like unexplained shortness of breath, persistent cough, or swollen lymph nodes
• Those with lung diseases, such as chronic granulomatous disease, that may affect ACE levels
• Individuals with a history of tuberculosis, certain cancers (like lymphoma), or other conditions that could impact ACE levels
• Patients already diagnosed with sarcoidosis who are being monitored for disease progression or response to treatment
• People experiencing unexplained symptoms related to inflammation or organ involvement, especially in the lungs or lymphatic system

The ACE test is not specific to a single disease, and while elevated ACE levels can suggest sarcoidosis or other inflammatory conditions, it is not a definitive diagnostic tool on its own. A combination of clinical symptoms, imaging studies (such as chest X-rays or CT scans), and other tests is often required to confirm a diagnosis. Sarcoidosis, which is the most common reason for an ACE test, typically affects the lungs, skin, eyes, and lymph nodes, though it can involve any organ. If the ACE test suggests an issue, further diagnostic testing and imaging may be required to identify the exact cause of the elevated levels and guide treatment decisions. For those already diagnosed with sarcoidosis, the ACE test can be used to monitor disease activity and treatment effectiveness over time.

• Angiotensin-converting enzyme blood test
• ACE enzyme test
• Serum ACE level