MYC (8Q24) Gene Rearrangements, Burkitt Lymphoma

What is Burkitt Lymphoma, MYC (8Q24) Gene Rearrangements test?

The Burkitt Lymphoma, MYC (8q24) Gene Rearrangements test is a molecular cytogenetic test that detects abnormalities involving the MYC gene located on chromosome 8q24. MYC gene rearrangement is a hallmark feature of Burkitt lymphoma, a highly aggressive type of B-cell non-Hodgkin lymphoma. Burkitt Lymphoma, MYC (8q24) gene rearrangements test is typically performed using the FISH technique to identify translocations involving MYC, most commonly t(8;14)(q24;q32), and less commonly t(2;8) or t(8;22). Detection of MYC gene rearrangement helps confirm the diagnosis and guide treatment decisions.

Why consider Burkitt Lymphoma, MYC (8Q24) gene rearrangements test?

Burkitt Lymphoma, MYC (8Q24) Gene Rearrangements test can be considered

• To confirm the diagnosis of Burkitt lymphoma by detecting characteristic MYC gene translocation.
• To differentiate Burkitt lymphoma from other aggressive B-cell lymphomas (like DLBCL or high-grade B-cell lymphoma).
• To provide prognostic information, as MYC rearrangements are linked to aggressive disease behavior.
• To assist clinicians in selecting intensive chemotherapy regimens suited for MYC-positive cases.
• To monitor treatment response or disease recurrence.

Who should get tested for Burkitt Lymphoma, MYC (8Q24) gene rearrangements test?

Burkitt Lymphoma, MYC (8Q24) Gene Rearrangements test is generally recommended for:

• Patients with suspected or histologically diagnosed Burkitt lymphoma.
• Individuals with aggressive B-cell lymphoma showing high proliferation index (Ki-67 > 90%).
• Cases where morphology and immunophenotype suggest MYC-driven lymphoma.
• Patients with relapsed or refractory high-grade B-cell lymphomas for molecular confirmation.

More Information

OTHER NAMES: MYC Rearrangement FISH Test, t(8;14) Burkitt Lymphoma Translocation Study, MYC (8q24) Translocation Detection by FISH, Burkitt Lymphoma Cytogenetic Panel

Lymphoma is a type of blood cancer that starts in the lymphatic system, which is part of the body’s immune system. It develops when certain white blood cells called lymphocytes (B-cells or T-cells) grow and multiply uncontrollably. Lymphoma can occur at any age, but some types are more common in older adults. Early detection and molecular profiling are essential for choosing the right therapy. Aggressive lymphomas often need rapid and intensive treatment, while indolent ones may be monitored initially. Lymphomas are broadly divided into two main categories which are Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL)