Cdc-crossmatch

What is CDC- Crossmatch Test?

The CDC crossmatch (Complement-Dependent Cytotoxicity crossmatch) is a laboratory test in organ transplantation to detect donor-specific antibodies (DSAs) in the recipient's serum that could cause graft rejection. This test is done before organ transplantation to check if the recipient has antibodies that can attack the donor’s cells. It involves mixing recipient serum with donor T and B lymphocytes, then adding complement. A positive test, indicating cell lysis (death), suggests a potential immune reaction and necessitates caution,

Why consider CDC- Crossmatch Test?

• To assess immunologic compatibility between a specific donor and recipient before transplant surgery.
• A negative CDC crossmatch supports proceeding with transplant; a positive result signals high risk for hyperacute/acute rejection and prompts alternative donor selection or desensitization.
• Complements other assays (flow crossmatch, HLA antibody testing) to provide an orthogonal, functional check of donor‑specific antibodies.

Who should get this CDC- Crossmatch Test?

• All solid organ transplant candidates (especially kidney) being evaluated against a specific living or deceased donor.
• Sensitized recipients (history of prior transplant, transfusions, or pregnancy) where donor‑specific antibodies are more likely.
• Recipients with ambiguous or conflicting antibody results who need a functional compatibility assessment with the intended donor.

More Information about CDC- Crossmatch Test

Complement-dependent cytotoxicity - Antibody binding plus complement leads to donor cell lysis; readout categorized as positive/negative for T and/or B cells. Helps prevent hyperacute/acute antibody-mediated rejection by confirming donor–recipient immunologic compatibility just before surgery; a positive, especially on T cells, is typically a strong contraindication unless desensitization or alternative plans are used.

OTHER NAMES: Complement-Dependent Cytotoxicity Crossmatch, CDC-XM / CDC Crossmatch (T- and B-cell), Antihuman Globulin (AHG)–Enhanced CDC Crossmatch, Donor–Recipient CDC Compatibility Test