LiquidSeq HRR Gene Panel (15 Genes)

What is Liquidseq HRR Gene Panel (15 Genes) test?

The Liquidseq HRR Gene Panel is a liquid biopsy test that analyses 15 genes involved in the homologous recombination repair (HRR) pathway. The HRR pathway is crucial for DNA repair. Defects in these genes can lead to genomic instability and increase the risk of certain cancers. Liquidseq HRR Gene Panel test is performed using a blood sample, providing a non-invasive method to detect mutations in genes related to DNA repair without the need for tissue biopsy. The panel targets 15 genes commonly associated with DNA damage response and repair, including BRCA1, BRCA2, ATM, PALB2, and others.

Why consider Liquidseq HRR Gene Panel (15 Genes) test?

Liquidseq HRR Gene Panel can be considered to:

• Identify mutations in HRR genes that may drive cancer development or progression.
• Guide targeted therapy decisions, especially the use of PARP inhibitors in cancers like breast, ovarian, prostate, and pancreatic cancer.
• Monitor treatment response and detect resistance mechanisms in real-time.
• Enable personalized precision oncology by tailoring therapy based on the patient’s molecular profile.

Who should get tested for Liquidseq HRR Gene Panel (15 Genes) test?

Liquidseq HRR Gene Panel can be recommended for:

• Patients with advanced or metastatic cancers where targeted therapy is being considered.
• Individuals with suspected hereditary cancer syndromes or family history of HRR-related cancers.
• Patients who cannot undergo tissue biopsy or require a non-invasive monitoring option.
• Patients being evaluated for PARP inhibitor therapy eligibility.

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OTHER NAMES: Liquid Biopsy HRR Panel (15 Genes), Circulating Tumor DNA HRR Gene Test, Liquidseq DNA Repair Gene Panel

HRR genes are genes involved in the Homologous Recombination Repair (HRR) pathway, which is a critical mechanism your cells use to repair double-strand breaks in DNA. Proper DNA repair is essential to maintain genomic stability and prevent mutations that can lead to cancer. When HRR genes are mutated, the cell’s ability to repair DNA damage is compromised, leading to genomic instability and an increased risk of cancer development. Testing HRR genes helps in personalized treatment planning, especially in breast, ovarian, prostate, and pancreatic cancers.