Multiple Myeloma Advance FISH Panel - 10 Markers
This FISH panel detects chromosomal abnormalities in multiple myeloma, including 10 specific markers. It helps in diagnosing the disease, predicting prognosis, and guiding treatment decisions.
Multiple Myeloma Advance FISH Panel - 10 Markers Test in Vadodara Overview
What is Multiple Myeloma Advance Panel by FISH – 10 markers test?
Multiple Myeloma Panel by FISH test is used to detect chromosomal abnormalities commonly associated with multiple myeloma, a type of blood cancer. This panel uses fluorescent probes to identify specific genetic translocations, deletions, or duplications that are often present in plasma cells in patients with multiple myeloma
This panel includes 10 key parameters - t(4;14), t(11;14), t(14;16), del17p, del13q, t(14;20) IGH/MAFB, 1p deletion/1q amplification, 5q/9q/15q for ploidy
Why consider Multiple Myeloma Panel by FISH test?
- This test provides crucial genetic information that helps oncologists determine the aggressiveness of the disease.
- Certain chromosomal abnormalities detected by the FISH panel, such as del(17p), are associated with high-risk disease and may prompt more aggressive or targeted treatment plans.
- The test also assists in identifying patients who may benefit from novel therapies or enrollment in clinical trials. Overall, it plays an essential role in risk stratification and individualized treatment planning.
Who should get this Multiple Myeloma Panel by FISH test?
- Newly diagnosed multiple myeloma to establish cytogenetic risk category as part of standard diagnostic workup.
- Smoldering myeloma or relapsed/refractory myeloma when risk reassessment may influence treatment choices or clinical trial eligibility.
- Related plasma cell disorders (e.g., plasmacytoma) when marrow involvement is sufficient and cytogenetic risk may inform clinical decisions.
More Information about Multiple Myeloma Panel by FISH test
Other Names: Myeloma FISH panel, Plasma cell myeloma FISH panel, Multiple myeloma FISH panel, Myeloma risk stratification panel
Multiple Myeloma (MM) belongs to a family of neoplasms involving clonal expansion of immunoglobulin-secreting B-cells, often with bone marrow involvement, resulting in anemia and leukopenia. Additionally, bone lesions are often seen. This FISH panel is designed to detect the most common, and/or prognostically significant abnormalities in Multiple Myeloma and related plasma cell neoplasms. Multiple myeloma arises from clonal plasma cells that accumulate in bone marrow and produce a monoclonal immunoglobulin (M-protein) or free light chains that can harm organs.
No special preparations needed
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- Total Number Of Cells
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Test code
6033F
Specimen vol. and vacutainer information
| Specimen | Vacutainer | Volume |
|---|---|---|
| Bone Marrow | Others | 2 ML |
Specimen stability information
Bone Marrow
Collection instructions
Non-Diluted Bone Marrow Collected In A Heparinized Syringe. Also Acceptable: Green (Sodium Heparin). Transfer 3 Ml Bone Marrow To A Green (Sodium Heparin) (Min: 1 Ml). Or Transport 5 Ml Whole Blood (Min: 2 Ml). Fluorescence In Situ Hybridization (Fish) Panel Is Performed On Cd138+ Sorted Cells (Assuming Specimen Is Sufficient For Sorting). If Sorting Fails To Yield Sufficient Cd138+ Cells, Testing Will Be Performed Using Unsorted Cells, If Available. Bone Marrow - Sodium Heparin +Sample Along With Clinical History Should Reach Within 24-48 Hours After Collection. Kindly Provide Clinico-Haematopathological Findings If Available Along With Trf.
Specimen rejection criteria
Test run frequency
'
Turn around time
10 Working Days
Performing locations
Department
- Cytogenetics
CPT and Loinc codes
Package price
₹18000
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₹18000