Homologous Recombinant Repair (HRR) Gene Panel

What is NGS Homologous Recombinant Deficiency [HRR] Panel test?

The NGS HRR Panel is a next-generation sequencing (NGS) test that analyzes multiple genes involved in the homologous recombination repair (HRR) pathway.

• HRR is a critical DNA repair mechanism that fixes double-strand breaks in DNA.
• Defects in HRR genes lead to genomic instability, which can drive cancer development and progression.

HRR genes are involved in DNA repair, cell cycle regulation, and tumor suppression. Mutations in them may increase cancer risk or predict therapy response.

Why consider NGS Homologous Recombinant Deficiency [HRR] Panel test?

Homologous Recombinant Deficiency [HRR] Panel test is valuable to:

• Detect hereditary or somatic mutations in HRR genes linked to cancer.
• Guide targeted therapy, especially PARP inhibitor therapy in cancers like breast, ovarian, prostate, and pancreatic cancer.
• Monitor tumor progression or treatment resistance in advanced cancers.
• Enable precision oncology strategies by tailoring treatment based on genetic profile.
• Evaluate risk for patients with a family history of HRR-related cancers.

Who should get tested for NGS Homologous Recombinant Deficiency [HRR] Panel test?

Homologous Recombinant Deficiency [HRR] Panel test is recommended for:

• Patients with advanced or metastatic cancers where targeted therapy is considered.
• Individuals with suspected hereditary cancer syndromes or strong family history of HRR-related cancers.
• Patients who cannot undergo tissue biopsy and require non-invasive genetic profiling (liquid biopsy may be used).
• Patients being evaluated for PARP inhibitor therapy eligibility.
• Clinicians seeking detailed molecular profiling to guide personalized cancer treatment.

More Information

OTHER NAMES: NGS DNA Repair Gene Panel, Homologous Recombination Repair Deficiency Panel, HRR Mutation Profiling Panel

HRR genes are genes involved in the Homologous Recombination Repair (HRR) pathway, which is a critical mechanism your cells use to repair double-strand breaks in DNA. Proper DNA repair is essential to maintain genomic stability and prevent mutations that can lead to cancer.

When HRR genes are mutated, the cell’s ability to repair DNA damage is compromised, leading to genomic instability and an increased risk of cancer development.

Testing HRR genes helps in personalized treatment planning, especially in breast, ovarian, prostate, and pancreatic cancers.