BRCA REFLEX

What is BRCA REFLEX (BRCA1 & BRCA2 BY NGS, GERMLINE AND MLPA)     test?

BRCA genes help repair damaged DNA. Mutations in these genes increase the risk of developing breast, ovarian, prostate, pancreatic, and other cancers. BRCA reflex is a genetic test that looks for changes (mutations) in the BRCA1 and BRCA2 genes using NGS and MLPA which detects large deletions or duplications in these genes.

Why consider BRCA REFLEX (BRCA1 & BRCA2 BY NGS, GERMLINE AND MLPA) test?

BRCA testing can be considered in mentioned below conditions:

• To assess hereditary risk for breast and ovarian cancer
• Helps in early detection, prevention, and treatment planning
• Informs decisions for Preventive surgeries (like mastectomy or oophorectomy), Screening strategies, Targeted therapies (e.g., PARP inhibitors)
• Beneficial for family members to understand their own risk

Who should get this BRCA REFLEX (BRCA1 & BRCA2 BY NGS, GERMLINE AND MLPA) test?

This test is typically recommended for:

• Individuals with personal or family history of breast, ovarian, pancreatic, or prostate cancer, cancer diagnosed at young age (e.g., breast cancer before 50), Triple-negative breast cancer and male breast cancer.
• People from populations with higher risk, such as Ashkenazi Jewish ancestry

• Anyone referred by an oncologist, genetic counselor, or gynecologist due to suspicion of hereditary cancer

More Information

OTHER NAMES: BRCA1 & BRCA2 Genetic Test, Germline BRCA Testing, BRCA Mutation Analysis (NGS + MLPA), Hereditary Breast and Ovarian Cancer (HBOC) Panel, BRCA Reflex Testing

BRCA1 and BRCA2 are two genes each of us inherits from their parents. These are termed tumor suppressors as they help prevent cells, including breast cells from growing and dividing uncontrollable. When BRCA1 and BRCA2 undergo mutations and fail to function normally, the risk of cancer increases. People who have inherited these mutations have a higher-than-average possibility of having breast cancers as well as ovarian cancers.