Glucose-6-Phosphate Dehydrogenase (G-6-PD) Test

 This test measures the activity of the glucose-6-phosphate dehydrogenase (G6PD) enzyme in red blood cells. G6PD deficiency is a genetic condition that can lead to hemolytic anemia when exposed to certain triggers like infections, medications, or foods (e.g., fava beans).

 The test is recommended for individuals with unexplained anemia, especially after exposure to known oxidative triggers, or those with a family history of G6PD deficiency. It’s also used in newborn screening in regions where the condition is prevalent.

 A blood sample is collected in an EDTA tube and analyzed in a lab to measure the enzyme activity level. The test is most reliable when the patient is not undergoing an acute hemolytic episode, as new red cells may skew results.

 Low G6PD activity indicates a deficiency and confirms the diagnosis. The severity can vary, with some individuals being asymptomatic and others experiencing life-threatening hemolysis. Normal levels suggest that the enzyme function is adequate.

 No fasting or special preparation is needed. However, informing your healthcare provider of recent symptoms or medications is helpful for accurate interpretation.