PD-L1 (SP 142)
PD-L1 SP142 testing evaluates the expression of PD-L1 on tumor cells and immune cells. It is crucial for selecting patients who may benefit from PD-1/PD-L1 inhibitor therapies.
PD-L1 (SP 142) Test in Bengaluru Overview
What is PD-L1 (SP 142) test?
The PD-L1 (SP142) test is an immunohistochemistry (IHC) assay that detects PD-L1 protein expression in tumor tissue, using the SP142 antibody clone. It's primarily used to guide immunotherapy decisions in various cancers—especially non-small cell lung cancer (NSCLC) and triple-negative breast cancer (TNBC).
Why consider PD-L1 (SP 142) test?
PD-L1 (SP142) test helps determine whether a patient may benefit from immunotherapy. PD-L1 (SP142) test is specifically validated for Guides Immunotherapy Decisions especially for Atezolizumab (Tecentriq) therapy.
Who should get this PD-L1 (SP 142) test?
The PD-L1 (SP142) immunohistochemistry (IHC) test should be performed in specific cancer patients where PD-L1 expression is required to determine eligibility for treatment with the immunotherapy drug atezolizumab.
- Patients with locally advanced or metastatic TNBC
- Patients with advanced or metastatic NSCLC
- Patients with locally advanced or metastatic urothelial carcinoma
More Information about PD-L1 (SP 142) test
PD-L1 (Programmed Death-Ligand 1) is a protein expressed on tumor cells and immune cells. It binds to PD-1 receptors on T cells and inhibits immune response, allowing tumors to evade detection. Drugs like atezolizumab, nivolumab, and pembrolizumab block this interaction, reactivating immune responses.
OTHER NAMES: Ventana PD‑L1 (SP142) Assay; PD‑L1 IHC SP142; PD‑L1 by IHC (SP142 clone); PD‑L1 (SP142) Ventana.
No special preparations needed
- Request Letter
- Additional Communication
- Pd-l1 (sp 142)
Test code
305AR00
Specimen vol. and vacutainer information
| Specimen | Vacutainer | Volume |
|---|---|---|
| Paraffin Block | Others | 100 MG |
| Tissue | Others | 10 |
Specimen stability information
Paraffin Block, Tissue
Collection instructions
Site Of Specimen/Clinical Detail/Primary Histopath Report.Mandatory If Tissue Received ,Tissue Processing Will Be Charged.
Specimen rejection criteria
Test run frequency
Every Day TIME - 18:30
Turn around time
3 Working Days
Performing locations
Department
- Coe Cytology
CPT and Loinc codes
Package price
₹9000
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₹9000