Autoimmune Encephalitis Panel-2 with DPPX

What is Autoimmune Encephalitis Panel-2 With DPPX, CSF test?

Autoimmune encephalitis (AE) is a group of neurological disorders where the immune system mistakenly attacks the brain. Autoimmune Encephalitis Panel-2 With DPPX, CSF is a comprehensive diagnostic test performed on cerebrospinal fluid (CSF) to detect autoantibodies associated with autoimmune encephalitis (AE) These antibodies target brain proteins and are linked with inflammation of the brain that can cause seizures, psychiatric symptoms, memory loss, movement disorders, and altered consciousness. DPPX is a protein found on the surface of neurons, involved in regulating neuronal excitability. DPPX-6 antibody test detects antibodies against DPPX (dipeptidyl-peptidase-like protein 6) in the cerebrospinal fluid (CSF).

Parameters Covered - NMDA, AMPA (GLUR1 + GLUR2), GABA B RECEPTOR, VGKC (LGI1,- CASPR2), DPPX.

Testing on CSF specimen is often preferred because some antibodies are only detectable in CSF, not blood. CSF antibodies usually correlate better with active brain inflammation.

Why consider Autoimmune Encephalitis Panel-2 With DPPX, CSF test?

Autoimmune Encephalitis Panel-2 With DPPX, CSF test is considered for

1. Early diagnosis of autoimmune encephalitis, which can mimic psychiatric illness, seizures, or infectious encephalitis.
2. Guide appropriate treatment - Identify specific autoantibodies linked to syndromes like Anti-NMDA receptor encephalitis, LGI1 encephalitis and CASPR2, GABA-B, AMPA receptor antibodies
3. Rule out infections or other causes of encephalopathy.
4. Provide diagnostic confirmation for unexplained neurologic or psychiatric symptoms.

Who should get tested Autoimmune Encephalitis Panel-2 With DPPX, CSF test?

Autoimmune Encephalitis Panel-2 With DPPX, CSF test is recommended for patients with sudden-onset neurologic or psychiatric symptoms that may include:

• Seizures (especially new or treatment-resistant)
• Psychosis, hallucinations, or behavioral changes
• Memory loss or confusion
• Abnormal movements (e.g., facial twitching, rigidity, tremors)
• Loss of consciousness or coma
• Suspected paraneoplastic syndromes (associated with cancer)

More Information about Autoimmune Encephalitis Panel-2 With DPPX, CSF test

Other Names: Autoimmune Encephalopathy Panel, Encephalitis Panel, Autoimmune Encephalitis Panel, Autoimmune Encephalitis antibody panel, Comprehensive Autoimmune Encephalitis Panel

Encephalitis is inflammation of the brain. It can be caused by viral or bacterial infections, or by immune cells mistakenly attacking the brain. Viruses that can lead to encephalitis can be spread by insects such as mosquitos and ticks.

When inflammation is caused by an infection in the brain, it's known as infectious encephalitis. And when it's caused by the immune system attacking the brain, it's known as autoimmune encephalitis. Sometimes there is no known cause.