Anti Centromere Antibodies

What is the Anti-Centromere Antibodies (ACA) test used for?

 The ACA test is primarily used to diagnose certain autoimmune conditions, especially limited cutaneous systemic sclerosis (CREST syndrome). It helps detect specific antibodies that target the centromere region of chromosomes.


How is the ACA test performed?

It requires a simple blood sample. The blood is analyzed in a lab to detect the presence and concentration of anti-centromere antibodies.


What do positive results mean?

A positive ACA test often indicates systemic sclerosis or related autoimmune diseases. It's especially associated with limited scleroderma.


Are there symptoms linked to a positive ACA test?

Yes, symptoms can include skin tightening, Raynaud's phenomenon, and esophageal issues, depending on the underlying autoimmune condition.


Can other conditions cause a positive ACA?

Rarely, other autoimmune diseases like Sjögren's syndrome or lupus may show weak ACA positivity, but it's most specific to limited scleroderma.