Lymphoma Aggressive Panel by FISH, Tissue

What is Lymphoma Aggressive Panel by FISH test?

Lymphoma Aggressive Panel by FISH is a specialized molecular cytogenetic test performed on tissue samples to detect rearrangements in the C-MYC, BCL2, and BCL6 genes. These gene abnormalities are commonly associated with aggressive forms of B-cell lymphomas, such as Diffuse Large B-Cell Lymphoma (DLBCL) and High-Grade B-Cell Lymphoma (Double Hit or Triple Hit Lymphomas). Lymphoma Aggressive Panel test uses the Fluorescence In Situ Hybridization (FISH) technique to visualize chromosomal rearrangements, helping in accurate classification and prognosis of lymphoma cases.

Why consider Lymphoma Aggressive Panel by FISH test?

Lymphoma Aggressive Panel by FISH test can be considered

• To identify aggressive genetic subtypes of B-cell lymphomas such as double-hit or triple-hit lymphomas.

• To aid in the accurate diagnosis and classification of lymphoma based on molecular features.
• To assess prognosis, as rearrangements in these genes are linked with poor outcomes and require more intensive therapy.
• To help guide targeted and risk-adapted treatment strategies.
• To differentiate between indolent and aggressive lymphoma types for appropriate management.

Who should get tested for Lymphoma Aggressive Panel by FISH test?

Lymphoma Aggressive Panel by FISH test is generally recommended for:

• Patients with suspected or confirmed B-cell lymphoma, especially Diffuse Large B-Cell Lymphoma (DLBCL).
• Cases showing high-grade or aggressive morphology on histopathology.
• Patients with relapsed or refractory lymphoma, to identify molecular mechanisms of resistance.
• Oncologists and pathologists seeking to classify lymphoma subtypes more precisely for treatment planning.

More Information

Other Names: Double/Triple Hit Lymphoma FISH Panel, BCL2/BCL6/MYC Rearrangement Study, Aggressive B-Cell Lymphoma FISH Panel

Lymphoma is a type of blood cancer that starts in the lymphatic system, which is part of the body’s immune system. It develops when certain white blood cells called lymphocytes (B-cells or T-cells) grow and multiply uncontrollably. Lymphoma can occur at any age, but some types are more common in older adults. Early detection and molecular profiling are essential for choosing the right therapy. Aggressive lymphomas often need rapid and intensive treatment, while indolent ones may be monitored initially.

Lymphomas are broadly divided into two main categories:

• Hodgkin Lymphoma (HL) which is characterized by the presence of Reed–Sternberg cells (abnormal large lymphocytes) and sually starts in lymph nodes in the neck, chest, or underarms.
• Non-Hodgkin Lymphoma (NHL) is a diverse group of blood cancers that include B-cell and T-cell lymphomas. These can be indolent (slow-growing) or aggressive (fast-growing).