HLA –A B C DR DQ Loci Typing by Histospot

What is HLA –A B C DR DQ LOCI Typing by HISTOSPOT test?

This test identifies an individual’s HLA type across key class I (HLA‑A, ‑B, ‑C) and class II (HLA‑DR, ‑DQ) loci using a bead/array-based platform (often referred to as “HistoSPOT”/Luminex-style or DNA-based typing), providing low-to-high resolution allele assignments. It defines the specific HLA alleles a person carries, which are critical markers of histocompatibility that guide donor–recipient matching and inform disease associations.

Why consider HLA –A B C DR DQ LOCI Typing by HISTOSPOT test?

• Improves donor–recipient matching for solid-organ and hematopoietic stem cell transplantation, reducing rejection, graft-versus-host disease, and improving graft survival.
• Helps interpret and manage donor-specific antibodies (DSA) and supports virtual crossmatch decisions when combined with antibody testing.
• Assists in diagnosing or assessing risk for certain autoimmune conditions linked to HLA types (e.g., celiac disease, ankylosing spondylitis), and supports pharmacogenetic and disease‑susceptibility research.

Who should get this HLA –A B C DR DQ LOCI Typing by HISTOSPOT test?

• Transplant candidates and potential living donors (kidney, liver, heart, lung; bone marrow/HSCT), to enable optimal HLA matching.
• Patients being evaluated for HLA-associated diseases or where HLA status may influence diagnosis/management.
• Family members undergoing related donor evaluation, and individuals being added to donor registries.

More Information

Other Names – HLA Typing, Human Leukocyte Antigen, HLA Typing High resolution, HLA Typing 6 Loci, HLA Typing by NGS, Solid Organ Transplantation, Kidney Transplant, Stem cell transplant, Bone marrow transplant

Human leukocyte antigens are of three main types. Class I HLA antigens include HLA-A, B, and C molecules; class II, which includes HLA-DR, -DQ, and -DP loci, are on antigen-presenting cells; and class III contains genes for proteins that have immune functionality.

HLA class I typing is used to identify HLA-matched platelets for alloimmunized refractory patients and identify presence of HLA antigens associated with a number of diseases or as drug hypersensitivity markers class I HLA antigens include A, B, and C loci.