HLA A, B, Dr Loci Typing PCR

What is HLA A, B, DR LOCI TYPING PCR Test?

This test identifies an individual’s HLA type across key class I (HLA‑A, ‑B, ‑C) and class II (HLA‑DR, ‑DQ) loci using a bead/array-based platform (often referred to as “HistoSPOT”/Luminex-style or DNA-based typing), providing low-to-high resolution allele assignments. It defines the specific HLA alleles a person carries, which are critical markers of histocompatibility that guide donor–recipient matching and inform disease associations.

Why consider HLA A, B, DR LOCI TYPING PCR Test?

• Transplant matching: Improves compatibility for kidney, marrow/hematopoietic stem cell, and other organ/tissue transplants, reducing acute and chronic rejection and graft loss.
• Immunologic risk assessment: Informs donor selection, allocation strategies, and the intensity of immunosuppression; foundational for virtual crossmatch and donor-specific antibody interpretation.
• Disease association and pharmacogenetic relevance: Certain HLA types associate with autoimmune diseases (e.g., HLA-B27 with spondyloarthropathy) and drug hypersensitivity (e.g., abacavir-HLA-B*57:01), and HLA profiling aids risk evaluation where indicated.

Who should get this HLA A, B, DR LOCI TYPING PCR Test?

• Transplant candidates and potential living donors for kidney, liver, heart, lung, pancreas, or HSCT who require precise HLA matching at A, B, and DR to optimize outcomes.
• Patients being evaluated for or monitored after transplant where accurate HLA typing is needed to interpret donor-specific antibody results and guide rejection risk management.
• Individuals undergoing workup for select autoimmune conditions or drug hypersensitivity where specific HLA associations are clinically actionable as per clinician request.

More Information about HLA A, B, DR LOCI TYPING PCR Test

OTHER NAMES: HLA Typing, Human Leukocyte Antigen, HLA Typing High resolution, HLA Typing 6 Loci, HLA Typing by NGS, Solid Organ Transplantation, Kidney Transplant, Stem cell transplant, Bone marrow transplant

Human leukocyte antigens are of three main types. Class I HLA antigens include HLA-A, B, and C molecules; class II, which includes HLA-DR, -DQ, and -DP loci, are on antigen-presenting cells; and class III contains genes for proteins that have immune functionality.

HLA class I typing is used to identify HLA-matched platelets for alloimmunized refractory patients and identify presence of HLA antigens associated with a number of diseases or as drug hypersensitivity markers class I HLA antigens include A, B, and C loci.