Spinocerebellar Ataxia Type 10

What is Spinocerebellar Ataxia Type 10 (SCA10) test?

Spinocerebellar Ataxia Type 10 (SCA10) is a rare hereditary neurodegenerative disorder caused by a repeat expansion of ATTCT pentanucleotide sequences in the ATXN10 gene.

This blood test, using an EDTA (purple-top) tube, is a genetic analysis designed to:

• Detect expanded ATTCT repeats in the ATXN10 gene
• Confirm a diagnosis of SCA10 in symptomatic individuals
• Assist in predictive testing for family members

Why consider Spinocerebellar Ataxia Type 10 (SCA10) test?

This test is used to:

• Diagnose SCA10 in individuals with progressive cerebellar ataxia symptoms
• Identify individuals with SCA10 mutations who are at risk of developing symptoms
• Guide genetic counseling and family planning
• Differentiate SCA10 from other types of ataxia, epilepsy, or movement disorders

Who should get tested for Spinocerebellar Ataxia Type 10 (SCA10) test?

This test is recommended for:

• Individuals with:

• Balance and coordination issues
• Progressive unsteady gait
• Speech difficulties (dysarthria)
• In some cases, seizures (epilepsy)

• People with a family history of hereditary ataxias
• Individuals of Latin American ancestry, especially Mexican, Brazilian, or other South/Central American backgrounds, where SCA10 is more prevalent
• Family members of someone already diagnosed with SCA10

More Information

OTHER NAMES: SCA10 Genetic Test, ATXN10 Repeat Expansion Test, Spinocerebellar Ataxia Type 10 DNA Analysis, Hereditary Ataxia Type 10 Testing, Autosomal Dominant Cerebellar Ataxia Type 10

Spinocerebellar Ataxia Type 10 (SCA10) is a progressive neurodegenerative disorder that primarily affects the cerebellum, the part of the brain responsible for coordination and balance. It is genetically inherited in an autosomal dominant pattern and caused by a repeat expansion mutation in the ATXN10 gene.