Holotc (holotranscobalamine), Active B12, Serum

The HoloTC (Holotranscobalamin) test measures the active form of vitamin B12 that is available for use by the body’s cells. It is considered a more accurate and early marker of vitamin B12 deficiency compared to total B12 tests. This test helps identify deficiency before symptoms appear or when standard B12 levels seem normal. Early detection through this test can help prevent long-term nerve and cognitive damage. The test is helpful in monitoring patients who are at risk of deficiency due to conditions like gastrointestinal disorders or certain medications.

Why consider HoloTC (Holotranscobalamin) test?

HoloTC (Holotranscobalamin) test is considered when there is a suspicion of vitamin B12 deficiency, especially in cases with symptoms like fatigue, weakness, or neurological issues. It helps detect deficiency earlier than traditional B12 tests. It’s also useful for people with conditions affecting B12 absorption, such as gastrointestinal disorders or after certain surgeries. Early detection allows prompt treatment to prevent serious complications.

Who should get HoloTC (Holotranscobalamin) test done?

• Individuals showing symptoms of vitamin B12 deficiency, such as fatigue, numbness, or memory problems.
• Patients with gastrointestinal conditions like Crohn’s disease, celiac disease, or pernicious anemia.
• People who have had bariatric or gastrointestinal surgery that may affect nutrient absorption.
• Older adults, who are at higher risk of B12 deficiency.
• Those taking medications that interfere with B12 absorption, such as metformin or proton pump inhibitors.
• Vegetarians or vegans, as they may have a lower dietary intake of B12.

More Information About HoloTC (Holotranscobalamin) test

The HoloTC (Active B12) test specifically measures the form of vitamin B12 that is available for cellular uptake, making it a more precise indicator of deficiency than total B12 levels. It can detect early B12 deficiency before changes in blood counts or symptoms appear. Often, it is used alongside other markers like methylmalonic acid for a thorough evaluation. Kidney function may influence results, so clinical context is important. Additionally, this test helps monitor how well patients respond to B12 treatment, ensuring effective management of deficiency.

Other Names: Active Vitamin B12, Holotranscobalamin II, Transcobalamin-Bound Vitamin B12, Active B12 Test