Dppx -6 Antibody, Csf

What is DPPX -6 ANTIBODY, CSF test?

DPPX-6 antibody test detects antibodies against DPPX (dipeptidyl-peptidase-like protein 6) in the cerebrospinal fluid (CSF). DPPX is a protein found on the surface of neurons, involved in regulating neuronal excitability. The presence of DPPX antibodies indicates an autoimmune neurological disorder, where the immune system attacks neuronal components.

DPPX-6 antibody test helps identify autoimmune encephalitis or neurological syndromes associated with DPPX antibodies.

Why consider DPPX -6 ANTIBODY, CSF test?

DPPX-6 antibody test can be considered to diagnose DPPX antibody-associated autoimmune encephalitis or encephalopathy.  Patients may present with symptoms like cognitive dysfunction (memory loss, confusion), Seizures, movement disorders, gastrointestinal symptoms (weight loss, diarrhea), sleep disturbances, autonomic dysfunction (blood pressure or heart rate changes). DPPX-6 antibody test helps distinguish autoimmune causes from infectious or other neurological diseases. Early diagnosis allows initiation of immunotherapy, which can improve outcomes.

 

Who should get this DPPX -6 ANTIBODY, CSF test?

DPPX-6 antibody test can be recommended for

 

• Patients with subacute onset neurological symptoms suggestive of autoimmune encephalitis.
• Those with unexplained encephalopathy, seizures, or movement disorders.
• Patients with refractory symptoms not explained by common causes like infection or metabolic disorders.
• Individuals with gastrointestinal and neurological symptoms combined, raising suspicion for DPPX antibody disease.
• Usually ordered by neurologists or specialists managing autoimmune neurological disorders.

 

More Information

Other Names: Anti-DPPX antibody test, Dipeptidyl-peptidase-like protein 6 antibody test, DPPX antibody-associated encephalitis testing

DPPX-6 antibody targets Dipeptidyl Peptidase-like Protein 6 (DPPX), a regulatory protein found on the surface of neurons. Antibodies against DPPX cause autoimmune attacks on neurons, leading to neurological dysfunction. The presence of DPPX antibodies is linked to an autoimmune encephalitis syndrome, sometimes called DPPX antibody-associated encephalitis.